ProSa is a powerful tool in protein structure research. ProSa supports and guides your studies aimed at the determination of a protein's native fold. It is helpful for experimental structure determinations and modeling studies.

Suppose you are confronted with the three-dimensional structure of a protein. The structure may have been determined by X-ray analysis or NMR-spectroscopy, it may be the result of modeling studies or it could be a nice looking structure deliberatly misfolded to fool specialists in protein structure theory. Obvious questions are:

• Is the structure correct ?
• Are there faulty parts ?

ProSa helps you to answer these questions.

ProSA-web

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Further information

• Read more about ProSaII at Sippl, M.J. (1993), Recognition of Errors in Three-Dimensional Structures of Proteins, Proteins 17, 355-362. pdf
• Survey of literature that cites above paper