Welcome to C.A.M.E. - the Center of Applied Molecular Engineering.
Our major research programmes concern the validation, refinement, prediction, and classification of protein structures. We develop computational tools and programs for protein domain decomposition, protein structure comparison and high speed structure data base searches. We use statistical thermodynamics and information theory to derive energy functions for protein structure validation, refinement and prediction. We employ Python and C/C++ for the implementation of computer source code. We share finished programs with the scientific and commercial communities.
Current major research projects include: Methods for the automated decomposition of protein structures into domains. Comparison and alignment of three-dimensional structures of proteins. Fast and sensitive structure data base searches. Understanding the forces that govern protein folding and protein stability.
Professor Manfred Sippl